Skin microbiome: novel discoveries on healthy skin, testing methods and regulations aspects

Skin microbiome: novel discoveries on healthy skin, testing methods and regulations aspects

06 October 2020, 14:30 - 19:00

Workshop Room 1
Language:
English

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Cosmetic and personal care products are launched with various claims that are linked to the skin microbiome and the interest in such development is growing. 

The understanding that the human body hosts various types of microbial lives in known since the discovery of the first bacteria by the Dutch microscopist Antonie van Leeuwenhoek in 1676. In early years of exploration and research bacteria was associated mainly with disease and epidemics. In modern times, we learned that some bacteria may be beneficial to our health.

Since the advancements of the techniques for genomic sequencing a shift has been created in research tools that allows for a different level of accuracy and information obtained about the microbiome when compared to the culturing techniques used prior to genomics.

While most of the research conducted on the human microbiome is associated with the digestive system, a growing wave of various projects is now focused on skin. Studying the skin microbiome is accompanied by opportunities and challenges. This workshop will collate experts from the Industry and Academia to discuss recent findings in skin microbiome mapping, research and regulatory aspects.

14:30 - 14:50     Developing skin microbiome related products - Frequently asked questions
Nava Dayan Ph.D., Owner, Dr. Nava Dayan LLC, Skin Care R&D Consulting

In recent years numerous active raw materials as well as finished products has been launched into the cosmetic market with claims referring to affect the skin microbiome either directly or indirectly.

The understanding that microorganisms exhibit profound impact to our wellbeing is rapidly developing. Scientific and medical community are working to study these effects, yet the practical means of implementation as well as regulatory landscape are shaping.

The skin microbiome, the population of resident and transient microorganisms on our skin is an emerging growing area of research and interest. The identification, classification, mapping, study of diversity, environmental implications and inferences to skin condition are key areas of investigation. 

Various molecular and in silico methods have been developed and employed in this area of research, but path to utilizing this knowledge in skin care product development is limited.

Dr. Nava's talk will provide a general overview on the exciting state of market landscape, research and development in this field.

14:50 - 15:25     Fact and fiction: how do we effect our skin microbiome?
Helen Knaggs Ph.D., Vice President, Nu Skin Enterprises Global Research and Development

Information on skin microbiome is an evolving, growing area with data rapidly emerging. This presentation will review what we currently know on the effect that interventions, such as personal care products, pollution and age have on skin microbiome and provide insight into how microbiome can be used for benefit in personal care.

15:25 - 16:00     Exploring the skin microbiome and medical implications
George Weinstock Ph.D., Professor and Director off Microbial Genomics, Jackson Laboratory for Genomic Medicine

A number of clinical scenarios involving the skin microbiome will be discussed including acne, psoriasis, diabetes as well as healthy individuals. In addition, new methodology for microbiome measurement and analysis will be presented.

16:00 - 16:30     Coffee and networking break

16:30 - 17:05     The regulatory status of microorganisms intended for skin care products in the EU
Atte von Wright Ph.D., Professor, Emeritus University of Eastern Finland

The regulatory network related to microorganisms intended for skin care products in the EU is quite complex. The products may fall into various categories, such as probiotics, novel foods, pharmaceuticals, medical devices or cosmetics, each subject to different legislation. The relevant Regulations for these specific cases will be briefly reviewed.

17:05 - 17:40     Direct modulation of the Cutibacterium population, the main commensal of the facial skin microbiome
Bernhard Paetzold Ph.D., Founder, S-Biomedic

Cutibacterium acnes is the main bacterial component of the skin microbiome on sebaceous and dry body sites  (Byrd et al. 2018). Despite its dominant role on the skin, many skin treatments aim at eradicating this bacterial species. Bernhard will present a selection of examples of the literature why this bacterial species is important to us and how it lives in a symbiotic relationship with its human host. Further Bernhard will present an example of how this population can be modulated at the strain level to address skin diseases (Karoglan et al. 2019).

17:40 - 18:15     The Hygiene Hypothesis (and why the personal care and cosmetic industry needs to care about it now more than ever)
Jim Hoffman, SVP of Strategic Alliances and Communications, AOBiome Therapeutics, Inc.

The Hygiene Hypothesis was first formulated in 1989 as an explanation for dramatic rises in childhood allergies.  Since that time, it has expanded to encompass critical health factors including immune response and inflammatory diseases impacting all ages. Often misunderstood, or worse unknown, it is a critical component of how both individuals and the products they use can impact their overall health.

18:15 - 18:50     Using 3D human skin models to evaluate beneficial ingredients and formulations, for damaged skin and microbiomes
Alex Chapman, Head of Operations, Labskin United Kingdom

The skin microbiome is an increasingly important topic in cosmetics and skincare, in this talk we discuss our recent results using a cultured 3D human cell model, as a platform to probe positive and negative effects of cosmetic ingredients and formulations, for both healthy and damaged skin and microflora.

18:50 - 19:00      Q&A’s

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Contributors

  • Nava Dayan Ph.D.

    Moderator

    Owner

    Dr. Nava Dayan LLC

    Nava Dayan Ph.D. Pharm has about 30 years of experience in skin care segment, and has yielded more than 150 publication credits in numerous...

  • Helen Knaggs Ph.D.

    Speaker

    Vice President

    Nu Skin Enterprises Global Research and Development

    Dr. Helen Knaggs has over 30 years of experience in skin research and product development, with years spent specializing in acne research. Her...

  • George Weinstock Ph.D.

    Speaker

    Professor and Director of Microbial Genomics

    Jackson Laboratory for Genomic Medicine

    Dr. George Weinstock is the Evnin Family Chair, Professor and Director of Microbial Genomics at the Jackson Laboratory for Genomic Medicine where he...

  • Atte von Wright Ph. D.

    Speaker

    Professor

    Emeritus University of Eastern Finland

    Atte von Wright graduated in General Microbiology from the University of Helsinki (Finland) in 1975 and received his PhD from the University of...

  • Bernhard Paetzold Ph.D.

    Speaker

    Founder

    S-Biomedic

    Bernhard completed his PhD in synthetic biology, working together in collaboration with the pharmaceutical industry to engineer bacteria as a living...

  • Jim Hoffman

    Speaker

    SVP of Strategic Alliances and Communications

    AOBiome Therapeutics, Inc.

    Jim Hoffman is the SVP of Strategic Alliances and Communications of AOBiome Therapeutics, Inc., a Cambridge, MA-based life sciences company focused...

  • Alex Chapman

    Speaker

    Head of Operations

    Labskin United Kingdom

    Alex has almost 20 years’ experience working in large and small companies, at a variety of levels. Alex trained as a Chemist while at the national...